منابع مشابه
Advances in flux balance analysis.
Biology is going through a paradigm shift from reductionist to holistic, systems-based approaches. The complete genome sequence for a number of organisms is available and the analysis of genome sequence data is proving very useful. Thus, genome sequencing projects and bioinformatic analyses are leading to a complete 'parts catalog' of the molecular components in many organisms. The next challen...
متن کاملConstrained Allocation Flux Balance Analysis
New experimental results on bacterial growth inspire a novel top-down approach to study cell metabolism, combining mass balance and proteomic constraints to extend and complement Flux Balance Analysis. We introduce here Constrained Allocation Flux Balance Analysis, CAFBA, in which the biosynthetic costs associated to growth are accounted for in an effective way through a single additional genom...
متن کاملP-value: What is and what is not
The misinterpretation and misuse of p-value have been increasing for decades. In March 2016, the American Statistical Association released a statement to warn about the use and interpretation of p-value. In this study, we provided a definition and discussion of p-value and emphasized the importance of its accurate interpretation.
متن کاملFlux balance analysis: a geometric perspective.
Advances in the field of bioinformatics have led to reconstruction of genome-scale networks for a number of key organisms. The application of physicochemical constraints to these stoichiometric networks allows researchers, through methods such as flux balance analysis, to highlight key sets of reactions necessary to achieve particular objectives. The key benefits of constraint-based analysis li...
متن کاملFinding Drug Targets with Flux Balance Analysis
Flux balance analysis (FBA) is an in silico metabolic analysis technique that has been used to identify potential drug targets in pathogens (disease-causing organisms) by determining essential biochemical reactions in these organisms [1]. To do this, previous studies have generally focused on completely removing each reaction in turn and checking if the pathogens can still survive, without quan...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2010
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.1614